相关实验视频
Updated: Jan 31, 2026

08:47
Endoscopic Cholesteatoma Surgery
Published on: January 19, 2022
13.0K
在内镜鼻手术中控制低血压的低压剂:系统性审查和网络元分析
Abdelrahman Saeed1, Omar Saeed1, Mohamedhen Vall Nounou2
1Faculty of Medicine, Al-Azhar University, Damietta, Egypt.
JAMA otolaryngology-- head & neck surgery
|January 29, 2026
概括
这项研究发现,几种低血压药物有效地减少了内镜鼻手术 (ESS) 期间的出血. 德克斯梅德托米丁最显著地降低了平均动脉压,而埃斯莫洛尔则帮助患者更快地康复.
科学领域:
- 麻醉学和手术的结果.
- 药理干预药理干预
- 基于证据的医学基于证据的医学.
背景情况:
- 在内镜外科手术 (ESS) 期间过度出血会损害手术可视化,增加并发症风险.
- 控制低血压是一种常见的策略,但不同药理学药物的比较有效性尚未得到充分证实.
研究的目的:
- 进行系统审查和网络元分析,比较各种低血压药物的有效性和安全性,以减少ESS的手术内出血.
- 确定最佳的药物,以提高外科领域的质量,同时保持患者的安全.
主要方法:
- 在PubMed,Scopus,Web of Science和Cochrane数据库中进行了全面的搜索,截至2025年5月.
- 包括52个随机临床试验 (3526名参与者) 评估德克斯梅德托米丁,克罗尼丁,埃斯莫洛尔,拉贝托洛尔,比索普罗罗罗尔,米托普罗罗尔,迪尔蒂亚泽姆,尼费迪平或维拉帕米尔与安慰剂.
- 数据提取和偏差风险评估遵循Cochrane指导方针;证据的确定性使用GRADE进行评分;网络元分析按照PRISMA指导方针进行.
主要成果:
- 与安慰剂相比,几种药物显著减少了出血:迪尔提亚泽姆,埃斯莫洛尔,德克斯梅德托米丁,拉贝塔洛尔和克洛尼丁.
- 德克斯梅德托米丁证明了平均动脉压 (MAP) 的最大降低,其次是克洛尼丁,埃斯莫洛尔和Labetalol.
- 比索普罗罗罗尔,维拉帕米尔和拉贝托洛实现了最大的心率降低;埃斯莫罗尔和拉贝托洛缩短了出现时间.
结论:
- 使用药理学药物的控制性低血压有效地提高了与安全性相关的ESS中的外科实地质量.
- 迪尔提亚泽姆,埃斯莫洛尔,德克斯梅德托米丁,拉贝塔洛尔和克洛尼丁被确定为减少出血的有效药物.
- 德克斯梅德托米丁在减少MAP方面最有效,而埃斯莫洛尔在患者的康复和出现时间方面显示出好处.
相关概念视频
Chemical Agents for Microbial Control
891
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
891
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Random and Systematic Errors
14.9K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.9K
Directing Effect of Substituents: meta-Directing Groups
6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K

