全球新生儿查先天性细胞巨乳病毒使用干血斑样本
Norma P Tavakoli1,2, Virginia Sack1, Andrew S Handel3
1Division of Genetics, Wadsworth Center, New York State Department of Health, Albany.
JAMA network open
|January 29, 2026
概括
新生儿对先天性细胞巨化病毒 (cCMV) 的查是可行的,并识别需要评估和治疗的婴儿. 在新生儿中早期检测cCMV提供了更好的结果,尽管产后感染也需要注意.
科学领域:
- 新生儿查和新生儿诊断
- 传染病 传染病 传染病
- 公共卫生 公共卫生
背景情况:
- 先天性细胞巨乳病毒 (cCMV) 是导致儿童感觉神经听力损失和神经障碍的主要非遗传原因.
- 目前缺乏普遍查导致许多新生儿未被诊断和未经治疗的cCMV疾病.
研究的目的:
- 评估使用干血斑 (DBS) 标本对新生儿进行cCMV查的可行性,查阳性率和家长接受度.
- 在基于人口的环境中评估cCMV查的诊断产量和影响.
主要方法:
- 一项基于人口的诊断研究选了新生儿DBS标本的CMV,同时进行了例行新生儿查.
- 量化聚合酶连锁反应 (PCR) 用于在DBS中检测CMV.
- 父母可以选择退出CMV结果;转诊的新生儿接受了后续评估和治疗.
主要成果:
- 在208,099名被查的新生儿中,529名 (0.3%) 的CMV查结果为阳性,其中276名 (0.1%总体) 被诊断为cCMV.
- 在68名新生儿中诊断出有症状的cCMV疾病 (24.6%的cCMV病例),其中70.6%接受抗病毒治疗.
- 在24.8%的转诊新生儿中发现了产后获得的CMV感染,突出显示了重要的同时发生的发现.
结论:
- 新生儿对cCMV的查是可行的,并使早期识别和评估成为可能,从而有可能改善结果.
- 查发现了先天性和显著比例的产后获得的CMV感染.
- 需要进行进一步的长期研究,以充分了解查的影响,特别是对无症状cCMV感染的影响.
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