白物质高强度负担和老年人驾驶表现下降
Madhur Parihar1, Yasheng Chen2, Byron Xu1
1Barrow Neuro Analytics Center, Barrow Neurological Institute, Phoenix, Arizona.
JAMA network open
|January 29, 2026
概括
老年人的白质超强度 (WMH) 负担与较差的驾驶表现和较高的撞车风险有关,特别是在后部区域. 抗高血压治疗可以减轻这些风险.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 运输安全运输安全
背景情况:
- 白质超强度 (WMH) 负担与老年人的认知能力下降有关.
- WMH对驾驶表现的影响以及可修改的风险因素的作用仍然不清楚.
研究的目的:
- 评估WMH负担与认知正常的老年人纵向驾驶表现之间的关联.
- 调查认知衰退和抗高血压治疗如何缓解这些关联.
主要方法:
- 在社区居住的老年人 (≥65岁) 的前性纵向队列研究.
- 基线MRI对WMH体积,车载驾驶持续监测和每年认知评估,平均随访时间为5.6年.
- 线性混合效应模型被用来分析关联,调整人口和血管风险因素.
主要成果:
- 较大的WMH负担与减少的驾驶频率,和独特的目的地有关.
- 较高的WMH负担预测这些驾驶指标的纵向下降速度更快.
- 后来的WMH增长与认知障碍患者的撞车风险增加有关.
- 抗高血压疗法显示了减轻WMH相关的危险驾驶的趋势.
结论:
- 增加WMH负担,特别是在后部区域,与驾驶自我调节受损以及老年人,特别是认知障碍患者的错误增加有关.
- 后部WMH可以作为生物标志物来识别有风险的司机.
- 在WMH的背景下,使用抗高血压药物可能有助于保持驾驶安全.
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