在马萨诸塞州 (2000-2023) 处方抑郁药过量死亡率:一个队列研究
Hannah Lee1, Huiru Dong1, Mohammad S Jalali1
1MGH Institute for Technology Assessment, Harvard Medical School, Boston, MA, 02114, USA.
Journal of general internal medicine
|January 29, 2026
概括
在马萨诸塞州,处方抑郁药过量死亡越来越多地涉及芬太尼,从早期的抗抑郁药和阿片类药物使用模式转变. 需要采取干预措施来解决持续的人口差异和多药制风险.
科学领域:
- * 药理学 药理学 药理学
- * 毒理学 毒理学 毒理学
- * * 公共卫生 公共卫生
背景情况:
- * 处方抑郁药,包括二, gabapentinoids 和 Z 药物,与严重的过量风险有关.
- *了解这些物质在过量致死事件中的普遍性及其与药物相关的药物对于公共卫生至关重要.
- * 识别处方抑郁剂过量死亡的模式,可以为有针对性的干预提供信息.
研究的目的:
- * 确定涉及处方抑郁剂过量死亡的不同潜在物质类别.
- *分析与这些物质类别相关的时间趋势和人口因素.
主要方法:
- *回顾性队列研究8,665致命的过量服用涉及处方抑郁药在马萨诸塞州 (2000-2023).
- *数据来源于马萨诸塞州生命记录和统计登记处,使用ICD-10代码和字面文本条目 (2015-2023年).
- * 隐性类别分析用于导出物质类别,并使用多项逻辑回归检查相关因素.
主要成果:
- *确定了五种潜在物质类别,其中最常见的是芬太尼,可卡因和二 (34.4%).
- *与芬太尼相关的类 (芬太尼,可卡因,二;芬太尼, gabapentin, xylazine) 随着时间的推移越来越占主导地位,而仅抗抑郁药类显著下降.
- *人口统计分析显示,涉及芬太尼的班级通常更年轻,更男性,更有可能在公共场合过量服用,与涉及抗抑郁药和处方阿片类药的老年,女性主导的班级形成鲜明对比.
结论:
- * 马萨诸塞州成千上万的过量服用死亡涉及处方药,这表明错过了干预机会.
- *持续的人口结构模式突显了老年女性多药制的长期趋势和处方中的种族差异.
- * 临床和政策干预,包括处方监测,停止处方和非法药物使用查,对于降低过量使用风险至关重要,特别是对妇女,老年人和种族少数群体来说.
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