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评估糖尿病视网膜病变中的系统性免疫炎症指数和死亡率:A NHANES 2005-2018年队列研究

Shuyang Guo¹, Yunlei Pang^2,3, Tong Bao²

¹Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.

Ophthalmology and therapy

|January 29, 2026

概括

系统性免疫炎症指数 (SII) 的升高与糖尿病视网膜病变 (DR) 的成年人死亡风险增加有关. 这一发现表明SII可能是DR患者长期结果的有价值的预后生物标志物.

科学领域:

眼科医生眼科眼科
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

糖尿病视网膜病变 (DR) 是可预防的失明和过度死亡的主要原因.
系统性炎症在DR病变发生过程中至关重要.
系统性免疫炎症指数 (SII) 是一种新的标志物,但其在DR中的预后价值尚不清楚.

研究的目的:

为了研究SII与美国50岁以上的DR成年人全因死亡率之间的关联.
评估SII作为长期死亡率的预后生物标志物在DR.

主要方法:

利用来自国家健康和营养检查调查 (2005-2018) 的全国代表性数据.
包括209名美国成年人,年龄≥50岁,患有DR.
通过2019年的国家死亡指数追踪死亡率状况.
使用了加权考克斯回归模型和受限立方线.

主要成果:

较高的SII与死亡风险增加有显著的关联 (HR=1.01).
在SII和死亡率之间观察到非线性关系.
随着时间的推移,SII显示出适度的死亡率预测能力 (AUC从0.762到0.576).
这种关联在人口和临床子组中持续存在.

结论:

由SII表示的系统性免疫炎症升高,独立地预测了DR的成年人的长期死亡率.
对于DR患者来说,SII显示出超越传统风险因素的预后生物标志物的潜力.

关键词:

糖尿病视网膜病变 - 糖尿病视网膜病变死亡率死亡率死亡率尼汉斯 (NHANES) 是一个名人.系统性免疫炎症指数

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