在老年住院患者中,药剂师主导的降低处方干预的有效性:一项实施研究,与追溯对照组进行了实践研究
Marci Dearing1,2, Susan K Bowles2,3, Jennifer E Isenor3
1Geriatric Medicine Research, Nova Scotia Health Authority and Dalhousie University, Halifax, NS, Canada.
European geriatric medicine
|January 29, 2026
概括
将药物负担指数 (DBI) 计算器©纳入药剂师评论中,有效地减少了老年住院患者的高风险药物使用. 这种工具支持抑郁症,显示出改善医院药物安全的希望.
科学领域:
- 老年人药房 老年人药房
- 药物经济学 药物经济学
- 临床药理学 临床药理学
背景情况:
- 多药和高风险药物 (抗胆固醇,镇静剂) 在老年人中普遍存在.
- 药物负担指数 (DBI) 计算器©是一个基于网络的工具,旨在量化药物负担.
研究的目的:
- 评估将DBI计算器©纳入医院药剂师药物优化中的有效性.
- 评估对高风险药物使用的影响,并探索实施促进者和障碍.
主要方法:
- 一个实施研究与追溯的控制组设计.
- 使用DBI计算器©进行的药剂师主导的药物审查是在四个医院病房中对70岁以上的患者进行的.
- 主要结果是DBI得分的变化;次要结果包括安全性,可行性和可信度. 通过混合方法探索实施情况.
主要成果:
- 在23%的干预组和6%的对照组 (p=0.003) 中,观察到DBI得分 (≥0.5) 的显著降低.
- 干预组中没有出现药物戒断不良事件.
- 采访表明,DBI计算器©支持放弃处方,但强调需要EMR整合和保护药剂师时间.
结论:
- 当DBI计算器©被整合到药剂师主导的药物评估中时,它有效地降低了老年住院患者的DBI得分.
- 该工具支持抑郁症的努力,证明了改善这种人群中药物管理的潜力.
- 需要进一步的研究来解决实施和可持续性,以便广泛采用.
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