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Design Example: Alignment of a Road Line Using GIS01:17

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Aligning actions are communicative strategies individuals employ to maintain social harmony and preserve personal identity in the face of potential disruptions to social norms. These actions are particularly important in managing social impressions when one's behavior might be seen as inappropriate, incompetent, or morally questionable.Types of Aligning ActionsThe three principal types of aligning actions are disclaimers, accounts, and apologies.DisclaimersDisclaimers are preventive; they are...
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Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
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趋势调整器:一种基于保留时间建模的特征调整方法,用于非定向LC-MS数据分析.

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  • 1Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06511, United States.

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概括
此摘要是机器生成的。

趋势调整器通过基于染色学原理的保留时间转移建模,准确地调整液体染色学-质谱学多态学数据中的特征,改进了跨运行的分析量化.

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科学领域:

  • 分析化学 分析化学
  • 生物化学 生物化学
  • 计算生物学 计算生物学

背景情况:

  • 在LC-MS多态学中,准确的交叉样本量化依赖于跨运行匹配的分析物.
  • 运行之间的保留时间转移需要专门的对齐算法.
  • 现有的算法往往忽视了控制保留时间转移的染色学原理.

研究的目的:

  • 介绍Trend-Aligner,这是一个用于非目标MS数据的新型特征对齐算法.
  • 显式模拟保留时间的变化,使用染色学原理进行分析智能校正.
  • 提高多态数据分析的准确性和可靠性.

主要方法:

  • 分解保留时间转移到全球 (非线性曲线) 和局部 (潜伏因子模型) 组件.
  • 模拟全球变化,捕捉色谱条件的系统变化.
  • 模拟局部转移,考虑分析物对染色学变化的特定反应.

主要成果:

  • 与11个现有的对齐算法相比,Trend-Aligner在各种代谢和蛋白质组数据集中表现出卓越的准确性.
  • 在特征对齐方面实现了高灵敏度和特异性.
  • 与MaxQuant相比,在MBR整合后发现的的增加为82.5%.

结论:

  • 趋势调整器 (Trend-Aligner) 提供了一个原则性的方法,用于在LC-MS多经济学中保持时间的调整.
  • 该算法增强了特征识别和量化准确度.
  • 趋势调整器为现实世界中的多态应用提供了显著的改进.