减少的刺激调节了小鼠在肌肉中的肌素分泌
Marin Kawasaki1, Chiho Kato1, Moe Tanigawa1
1Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
PloS one
|January 29, 2026
概括
由于软饮食而减少,会损害马塞特肌肉的生长,改变肌蛋白信号传递,促进脂肪积累,影响全身新陈代谢. 保持足够的口对于代谢平衡至关重要.
科学领域:
- 生物医学科学 生物医学科学
- 肌肉生理学 肌肉生理学
- 代谢调节 代谢调节 代谢调节
背景情况:
- 对于口腔功能和代谢健康至关重要.
- 由于软饮食减少了口负荷对肌肉蛋白信号传递的影响尚不清楚.
研究的目的:
- 为了研究减少口如何影响来自肌肌肉的肌素分泌.
- 评估对肌肉发育和全身代谢调节的影响.
主要方法:
- 雄性C57BL/6J小鼠被食硬或软饮食1周或7周.
- 通过qPCR和免疫组织化学评估的体重,肌肉/脂肪质量,纤维大小和肌酸蛋白表达 (IL-6,IL-10,TNF-α,Nfkb1,肌酸蛋白) .
主要成果:
- 长期的软饮食养减少了肌肉质量和纤维大小,增加了脂肪积累,并改变了肌蛋白的配置.
- 具体来说,IL-6和IL-10降低了,而TNF-α,Nfkb1和myostatin (Mstn) 增加了,这表明抑制了代谢和增强了代谢途径.
结论:
- 减少的刺激会对肌和全身新陈代谢产生负面影响.
- 负荷通过肌信号调节面肌肉发育和代谢平衡.
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