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Updated: Jan 31, 2026

Photo-Induced Cross-Linking of Unmodified Proteins PICUP Applied to Amyloidogenic Peptides
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Published on: January 12, 2009

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DNA-蛋白质交叉链促进cGAS-STING驱动的过早衰老和胚胎死亡率

Ines Tomaskovic1, Cristian Prieto-Garcia1, Maria Boskovic1,2

  • 1Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt, Germany.

Science (New York, N.Y.)
|January 29, 2026
PubMed
概括

DNA-蛋白质交叉链接 (DPCs) 导致有毒的DNA损伤和免疫激活. 金属蛋白酶SPRTN阻止了这一点,其损失导致了类似于前列腺的衰老和胚胎死亡,可以通过抑制cGAS-STING通路来挽救.

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