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对于TP53突变的AML,德西的合成致死性加上ATR抑制

Jeremy T Baeten1, Sumedha Agashe1, Imene Tabet1

  • 1Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.

Blood advances
|January 29, 2026
PubMed
概括

骨髓瘤瘤中的TP53突变会使预后恶化. 将德平与ATR抑制剂结合起来,通过利用TP53突变急性髓性白血病中德平诱导的复制应激来提供一种新的治疗策略.

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