在中国人口中, perfluoroalkyl 和 polyfluoroalkyl 物质与血红蛋白之间的结构依赖关系:从流行病学分析和分子模拟的见解
Xuedan Xu1, Keqi Hu2, Yingli Qu3
1Guangdong Provincial Center for Disease Control and Prevention, Institute of Environmental and School Health, Guangzhou, Guangdong 511430, China.
Environment international
|January 29, 2026
概括
和多基基物质 (PFAS) 与一般人群中较低的血红蛋白 (Hb) 水平有关,特别是在女性中较长链的碳酸 (PFCAs). 分子建模表明,PFAS可能会干扰氧结合.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 人类生物监测 人类生物监测
背景情况:
- 和多基基物质 (PFAS) 是广泛存在的环境污染物.
- 在一般人群中,PFAS暴露与血红蛋白 (Hb) 水平之间的关系尚不清楚.
- 了解PFAS和Hb之间的结构功能关系对于评估血液毒性至关重要.
研究的目的:
- 调查大量中国人群中血清PFAS度与Hb水平之间的关联.
- 通过使用计算方法探索潜在的PFAS-Hb关系的分子机制.
- 确定特定的PFAS化合物和受这些关联影响最严重的人口子组.
主要方法:
- 来自中国国家人类生物监测计划 (n=6,883) 的血清PFAS度和Hb水平的分析.
- 对8个PFAS和Hb之间的个人和联合协会的统计检查.
- 应用分子对接和量子力学计算来预测PFAS和HB之间的相互作用.
主要成果:
- 在PFAS混合物和Hb度之间观察到负相关性.
- perfluoroundecanoic 酸 (PFUnDA) 是反向关联的主要贡献者.
- 长链完全碳酸 (PFCAs) 和Hb之间的不良关联在女性中更强烈.
- PFAS优先结合Hb的α子单元,可能会干扰氧结合.
结论:
- PFAS暴露与一般人群中的Hb水平降低有关,具有结构依赖的影响.
- 女性,BMI较低的个体,以及肉类消费较高的个体显示出更强烈的关联.
- 这些发现凸显了PFAS的潜在血液毒性,以及对暴露控制的必要性.
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