一种绿色和高效的酸亲和固体相提取策略,用于基于树突性中性二氧化的银酸丰富
Weiman Zhao1, Longchan Liu1, Wenxiang Fan1
1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, The MOE Key Laboratory of Standardization of Chinese Medicines, The SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Journal of chromatography. A
|January 29, 2026
概括
一种新的酸纳米材料可以有效地将植物中的金色化物分离出来. 这种绿色方法提高了净化,产生了更高的回收和识别比传统技术更多的化合物.
科学领域:
- 自然产品化学 自然产品化学
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 从Panax植物中提取的金色化物具有显著的生物活性,但难以分离.
- 对于人参化物来说,传统的分离方法是低效的,昂贵的,对环境不友好,使用过多的有机溶剂和复杂的工艺.
研究的目的:
- 开发一种高效,绿色的固体相提取 (SPE) 方法来分离和净化金色化物.
- 为了利用一种新型的酸功能化的树突性半孔性二氧化纳米材料来隔离金氏化物.
主要方法:
- 构建一个酸功能化的半孔二氧化纳米材料.
- 纳米材料的应用作为SPE吸收剂,用于Panax notoginseng中产生的人参化物.
- 使用单因素实验和Box-Behnken响应表面方法来优化提取参数.
- 使用带有充电气溶检测的高性能液体染色学 (HPLC-CAD) 和超高性能液体染色学-四极飞行时间质谱学 (UPLC-Q-TOF-MS) 分析人参酸.
主要成果:
- 开发的亲和SPE策略实现了比宏树脂 (3.4-4.0对1.7-2.0) 高2.0倍的丰富系数.
- 对于主要的金氏化物,获得了高吸附率 (93.5-98.7%) 和脱吸率 (88.9-97.9%) 的恢复.
- 在UPLC-Q-TOF-MS分析中,发现了127种金氏化物,并显著减少了非金氏化物干扰.
- 绿色评价证实了亲和战略的环保性和可持续性.
结论:
- 使用功能化纳米材料的亲和SPE为高效和绿色的金氏化物净化提供了优质的替代方案.
- 这种方法对大规模制备含有cis-diol基因的金色化物和其他天然产品具有前景.
- 与传统技术相比,该方法显著提高了分离效率,回收率和化合物识别.
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