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Updated: Jan 31, 2026

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在日本的现实环境中,在多发性硬化症患者中进行了一项多中心的回顾性研究,这些患者接受了纳塔利祖马布治疗:REFIND研究
Ichiro Nakashima1, Takashi Ohashi2, Kazumasa Yokoyama3
1Division of Neurology, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi 983-8536, Japan.
Multiple sclerosis and related disorders
|January 29, 2026
概括
在日本,纳塔利祖马布的延长间隔剂量 (EID) 与标准间隔剂量 (SID) 在治疗复发性复发性多发性硬化症 (RRMS) 中同样有效. EID和SID/EID疗法显著降低了年度复发率和新的T2病变.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 纳塔利祖马布 (TYSABRI) 是有效的复发性复发性多发性硬化症 (RRMS) 在标准间隔剂量 (SID).
- SID与渐进式多焦点白血脑病 (PML) 的风险增加有关.
- 纳塔利祖马布的延长间隔剂量 (EID) 可以降低PML风险,同时保持有效性.
研究的目的:
- 为了检查日本的现实世界纳塔利祖马布剂量模式.
- 评估与纳塔利祖马布剂量模式 (SID,EID,SID/EID) 相关的MS疾病活性.
主要方法:
- 在日本120名RRMS患者接受纳塔利祖马布治疗的回顾性观察研究 (REFIND).
- 患者根据平均剂量间隔被分为SID-only,EID-only或SID/EID组.
- 年复发率 (ARR) 和新的/扩大的T2病变,与纳塔利祖马布开始前后相比.
主要成果:
- 只有EID (45.9天) 和SID/EID (38.7天) 组显示出显著的ARR降低 (分别为97.9%和91.7%).
- 仅在SID组 (30.8天) 中没有观察到显著的ARR降低.
- 在所有组中,新的/扩大的T2病变减少,EID和SID/EID组显著减少.
结论:
- 在日本的现实环境中,EID和SID/EID疗法在减少RRMS疾病活动方面表现出与SID相似的疗效.
- 在控制疾病活性方面,纳塔利祖马布的有效性在不同剂量模式中是一致的.
- 这些发现可能会为亚洲人群的纳塔利祖马布治疗选择提供信息.
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