在亚马逊河流人口中,与慢性暴露相关的基于血液的转录组概况
Nathalia de Assis Aguilar Duarte1, Lucas Cassulatti Dos Santos2, Flora Troina Maraslis2
1University of Sao Paulo, School of Pharmaceutical Sciences of Ribeirao Preto, Department of Clinical Analyses, Toxicology and Food Sciences, Analytical and System Toxicology Laboratory, Ribeirão Preto, São Paulo, Brazil; Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, Santos, Brazil.
Journal of hazardous materials
|January 29, 2026
概括
亚马逊地区的慢性暴露会改变全血中的基因表达,影响与压力和炎症相关的途径. 这项研究揭示了与河流社区的水平相关的分子变化.
科学领域:
- 环境健康 环境健康
- 基因组学就是基因组学.
- 毒理学 毒理学 毒理学
背景情况:
- 长期暴露于 (Hg) 是亚马逊河流社区的重大公共卫生问题,原因是受污染的鱼类消费.
- 了解暴露对分子的影响对于制定有效的公共卫生战略至关重要.
研究的目的:
- 通过全基因组全血转录基因分析,研究与慢性暴露相关的分子模式.
- 为了确定受不同程度暴露影响的生物途径,在一个脆弱的人群中.
主要方法:
- 在巴西亚马逊地区对95名成年人进行横截面研究,对血液Hg度进行生物监测.
- 使用微阵列分析进行全基因组全血转录基因组分析.
- 差异基因表达分析和功能丰富分析以确定受影响的途径.
主要成果:
- 与对照组相比,成千上万的转录在中度和高Hg暴露组中显示出改变的表达.
- 关键受影响的途径包括氧化应激,炎症/免疫信号,DNA损伤反应和细胞应激调节.
- 中度Hg暴露与适应性压力和代谢途径有关,而高暴露涉及炎症和亡过程.
结论:
- 这项研究提供了第一个全基因组转录的见解,在现实条件下,在亚马逊人口中对慢性Hg暴露提供了第一个基因组范围的见解.
- 研究结果强调了Hg的广泛分子影响,影响了压力,炎症和细胞过程.
- 未来的研究应该包括细胞类型调整和纵向设计,以获得精细的机理学解释和公共卫生指导.
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