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Updated: Jan 31, 2026

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一个优化的体外消化协议,用于在植物性食品矩阵中评估零价值铁纳米粒子
Julita Nowosadko1, Zuzanna Szymańska1, Monika Kupiec1
1Warsaw University of Technology, Faculty of Chemistry, Chair of Analytical Chemistry, Noakowskiego 3, 00-664 Warsaw, Poland.
Food chemistry
|January 29, 2026
概括
零价值铁纳米粒子 (Fe(0) NPs) 在模拟消化过程中发生变化. 胃病导致溶解和聚合,而肠道病则部分逆转,影响食品系统中铁的生物可获得性.
科学领域:
- 环境科学 环境科学
- 食品科学 食品科学 食品科学
- 纳米技术纳米技术
背景情况:
- 零价值铁纳米粒子 (Fe(0) NPs) 用于农业和食品生产.
- 有关Fe(0) NP摄入后的稳定性和生物可访问性存在担忧.
研究的目的:
- 在模拟的口腔-胃-肠消化过程中调查Fe(0) NP转化.
- 优化用于含有FeNP的植物样本的INFOGEST 2.0协议.
主要方法:
- 使用了STEM成像,单颗粒ICP-MS/MS和总铁量测量.
- 通过使用FeNP丰富的番茄组织和CRM番茄叶来调整和验证INFOGEST 2.0协议.
主要成果:
- 唾液氨酶没有影响Fe(0) NPs或植物基质.
- 胃消化 (素) 诱导的溶解和聚合超过70g·L-1.1.
- 肠道消化 (胰腺素) 部分逆转溶解,产生颗粒,聚合物和离子铁.
结论:
- 在体外研究中,建议优化酶度 (0.5 g·L−1氨酶,70 g·L−1素,7 g·L−1胰腺素).
- 在食品系统中Fe(0) NP转化和生物可访问性取决于消化阶段.
- 植物中铁的分布有所不同,根部的铁积累最多.
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