在体质症状障碍中,皮层形态变化和破坏的结构共变性网络
Yong Guo1, Xinxue Gao1, Jiayi Liu2
1Department of Psychiatry, Shandong Daizhuang Hospital, Jining, 272000, China.
Journal of affective disorders
|January 29, 2026
概括
身体症状障碍 (SSD) 患者表现出皮质厚度和表面积的改变,以及结构共变网络 (SCN) 的破坏. 这些大脑变化可能作为SSD的神经成像标记.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 以前的研究表明,在体质症状障碍 (SSD) 中,灰质体积 (GMV) 发生变化.
- 在SSD中,皮层形态和大脑网络组织的具体情况仍然不清楚.
- 本研究研究了SSD中的皮层厚度 (CT),表面积 (SA) 和结构共变性网络 (SCN).
研究的目的:
- 在SSD患者中检查皮质结构变化 (CT和SA).
- 探索SSD大脑中的结构共变性网络 (SCN) 的破坏.
- 为了确定SSD的潜在神经成像标记物.
主要方法:
- 从50名SSD患者和60名健康对照 (HC) 获得高分辨率T1加权MRI.
- 使用FreeSurfer评估CT和SA的群体差异.
- 构建了SCN并使用图形理论分析来评估网络拓.
主要成果:
- 在SSD患者中,左上额头,左侧三角和双侧面中额头的CT缩小.
- 在右面面中额回形中CT与体质症状严重程度负相关.
- 基于CT的SCN分析显示右半球的节点度增加和更高的小世界性;基于SA的SCN分析显示左半球的节点效率下降.
结论:
- 皮层结构的改变和SCN组织的破坏在SSD中很明显.
- 这些神经成像发现可能为SSD的神经生物学基础提供了洞察力.
- 发现的异常可以作为SSD的潜在生物标志物.
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