胡油和糖果在儿科刺激性肠综合征和功能性腹痛:一个随机试验
N K Vermeijden1, C van der Feen2, M Groeneweg3
1Emma's Children Hospital, Amsterdam UMC, location AMC, University of Amsterdam, Pediatric Gastroenterology, Hepatology and Nutrition, Amsterdam, the Netherlands; Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centers, Location Academic Medical Center/Emma Children's Hospital, Amsterdam, the Netherlands; Amsterdam UMC, University of Amsterdam, Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, Netherlands; Department of Pediatrics, St Antonius Hospital, Nieuwegein, The Netherlands.
与安慰剂相比,胡油和糖果并没有有效治疗儿科刺激性肠综合征 (IBS) 或功能性腹痛 (FAP-NOS). 对于这些情况,建议进行肠-大脑轴干预.
科学领域:
- 胃肠病学 胃肠病学
- 儿科医学 儿科医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科刺激性肠综合征 (IBS) 和功能性腹痛-未另行说明 (FAP-NOS) 的药理疗法有限.
- 胡油是一种抗药,是这些疾病的潜在治疗选择.
研究的目的:
- 评估胡油和胡薄荷糖果在被诊断为IBS或FAP-NOS的儿童中的疗效和安全性.
- 将这些干预措施与随机对照试验中的安慰剂进行比较.
主要方法:
- 这是一项随机对照试验,涉及13家荷兰医院的228名儿童 (8-18岁).
- 参与者每天两次或三次接受双盲薄荷油囊,开放标签的薄荷糖果或双盲安慰剂,持续8周.
- 治疗的成功被定义为8周后腹痛强度减少≥30%.
主要成果:
- 在胡油 (44.0%) 和安慰剂 (37.3%) (P=0.44) 之间没有观察到治疗成功的显著差异.
- 与安慰剂相比,薄荷糖也没有显著差异 (38.7%与37.3%,P=0.91).
- 在所有组中,充分的症状缓解是可比的,不良事件是轻微的和不频繁的.
结论:
- 无论是薄荷油还是薄荷糖果都没有在治疗儿科IBS和FAP-NOS方面比安慰剂表现出优越性.
- 这项研究表明,针对肠-大脑轴的干预措施应优先考虑在儿童中管理这些疾病.
相关概念视频
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome III: Medical and Nursing Management
Clinical Trials: Overview
Trial and Error and Algorithm
Clinical Trials
There are four phases in a clinical trial. A phase one...


