健康受试者的脑电图功率,连接性和网络动态的psilocybin诱导的改变:与主观经验的相关性以及对治疗应用的含义
Cheng-Teng Ip1, Sebastian Olbrich2, Mateo de Bardeci2
1Centre for Cognitive and Brain Sciences, University of Macau, Taipa, Macau, SAR, China; Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau, SAR, China.
Progress in neuro-psychopharmacology & biological psychiatry
|January 29, 2026
概括
西会改变大脑活动,减少缓慢的脑电图波,增加快速的脑电图波,同时提高网络连接. 这些神经生理学变化与主观经验相关,这表明心理健康治疗的潜力.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 临床心理学 临床心理学
背景情况:
- 西在治疗精神障碍方面表现有前途.
- 了解psilocybin对大脑功能的影响至关重要.
- 识别响应预测因素可以优化治疗用途.
研究的目的:
- 为了研究psilocybin对脑电图 (EEG) 功率和网络连接的影响.
- 探索基线EEG特征是否预测了对西的主观反应.
主要方法:
- 这是一项双盲,随机,交叉,安慰剂控制的研究,涉及25名健康成年人.
- 脑电图记录 (静止状态) 在基线和药物效应峰值时进行.
- 在默认模式网络 (DMN) 和皮层网络中分析了EEG功率和连接性.
主要成果:
- 松素降低了慢波EEG功率 (乙,α) 和增加了快波功率 (β,γ).
- 在DMN和状网络中观察到连接性增加.
- 主观体验与EEG功率和连接变化有积极的相关性.
结论:
- 西显著改变大脑活动,影响EEG功率和网络连接.
- 神经生理学变化与主观经验相关,支持治疗潜力.
- 基线EEG特征可以预测反应,帮助个性化的psilocybin治疗.
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