固体/液体界面的能量与制药悬浮物的物理稳定性之间的潜在相关性
Nadina Zulbeari1, Magnus Jæger Dixen1, Sebastian Black1
1Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark.
International journal of pharmaceutics
|January 29, 2026
概括
这项研究研究了非离子表面活性剂如何与表面相互作用以及它们对制药悬浮液稳定性的影响. 界面测量提供了洞察力,但单独不足以预测药物颗粒的物理稳定性.
科学领域:
- 制药科学 制药科学
- 物理化学 物理化学
- 材料科学 材料科学 材料科学
背景情况:
- 非离子表面活性剂在制药配方中对于稳定悬浮剂至关重要.
- 了解界面行为是预测配方性能的关键.
- 悬浮的界面能量和物理稳定性之间的关系需要进一步研究.
研究的目的:
- 研究非离子表面活性剂在空气-液体和固体-液体界面上的界面行为.
- 为了确定各种表面活性剂-药物化合物相互作用的粘附作用.
- 探索药物悬浮剂的界面特性与物理稳定性之间的相关性.
主要方法:
- 使用吊滴张力计测量七种非离子表面活性剂的表面张力测量.
- 对八种模型药物化合物的表面活性剂溶液的接触角度测量.
- 通过在40°C下28天监测颗粒大小变化来评估药物悬浮物的物理稳定性.
主要成果:
- 非离子表面活性剂显著降低了水的表面张力,效率各不相同.
- 所有测试的表面活性剂溶液都在药物化合物表面表现出有利的扩散 (接触角度<90°).
- 虽然观察到粘附工作和悬浮稳定性之间的一些相关性,但没有建立一致的预测趋势.
结论:
- 界面能量测量提供了关于表面活性剂行为和固体-液体相互作用的宝贵数据.
- 单独的界面特性并不是药物悬浮物质稳定性的足够预测因素.
- 需要进一步的研究来开发全面的模型来预测配方稳定性.
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