激活调节的刺激反应系统:一个智能平台,用于对不同治疗药物的特定部位的胃补充剂输送
H N Shivakumar1, Rushikesh Shinde2, Vanita Somasekhar3
1Centre of Innovative Science and Engineering Education, Department of Pharmaceutics, KLE College of Pharmacy, Rajajinagar, Bengaluru 560010, India; KLE Academy of Higher Education and Research, Belagavi, India.
International journal of pharmaceutics
|January 29, 2026
概括
激活调制刺激响应系统 (AMS) 或飞形成系统 (RFS) 提供创新的胃刺激药物递送. 这些pH触发系统在胃中形成漂浮的凝,改善药物吸收,并使有针对性的胃作用.
科学领域:
- 制药科学 制药科学
- 药物输送技术 药物输送技术
- 生物材料工程 生物材料工程
背景情况:
- 激活调制刺激响应系统 (AMS),也称为飞形成系统 (RFS),代表了胃药物输送的新方法.
- 这些系统利用电离子凝来将液体配方转化为浮力,粘性凝在与胃离子接触时,由pH值变化引发.
研究的目的:
- 提供关于AMS的组成,制定策略,评估技术和应用的全面审查.
- 突出AMS的最新进展,包括智能聚合物,多响应系统,纳米技术集成和3D打印.
主要方法:
- 对AMS和胃食药物输送系统的现有文献的审查.
- 分析pH触发凝和药物释放的机制.
- 探索配方组件,如智能水友性聚合物,泡剂和交联剂等.
主要成果:
- AMS有效地延长了药物在胃中的停留时间,使局部胃作用成为可能,并减少了全身暴露.
- 这些系统可以通过调节微环境pH值来提高在酸性环境中具有溶解性或稳定性挑战的药物的生物可用性.
- 最近的创新包括多响应和纳米技术集成的AMS,以及3D打印系统.
结论:
- AMS为改善药物吸收和治疗结果提供了一个独特而有前途的平台,特别是对于需要胃作用或表现出低生物可用性的药物.
- 尽管在配方稳定性和扩展方面存在挑战,但AMS具有显著的翻译潜力,并获得了大量的商业和监管利益.
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