狭宽表面声波装置驱动的嗅觉上皮向的鼻内原子化.
Kosuke Wakayama1, Sho Kurihara2, Yuta Kurashina1
1Division of Advanced Mechanical Systems Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei-shi, Tokyo 184-8588, Japan.
International journal of pharmaceutics
|January 29, 2026
概括
一个新的鼻内原子化系统针对嗅觉上皮质直接向大脑输送药物. 这种窄宽表面声波 (NWSAW) 装置有效地传递药物,绕过血脑屏障.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 神经科学是一个神经科学.
背景情况:
- 鼻内药物输送提供了一条入侵性最小的途径进入大脑,绕过血脑屏障 (BBB).
- 传统的鼻腔器械难以到达鼻腔深处的嗅觉上皮,限制了直接进入大脑的途径.
- 有效的传递到嗅觉上皮质对于针对大脑的鼻内注射至关重要.
研究的目的:
- 开发和评估一种新的鼻内原子化系统,以有针对性地向整个嗅觉上皮进行输送.
- 克服传统设备在达到深鼻腔的局限性.
- 评估拟议的脑药物输送系统的疗效和药物完整性.
主要方法:
- 制造一个窄宽表面声波 (NWSAW) 装置 (宽度为5毫米),用于鼻内插入.
- 原子化特性 (角度,颗粒大小) 的表征和与标准鼻喷雾剂的比较.
- 扩展LBNA (Ex-LBNA) 装置的评估,用于更深的鼻腔插入和整个嗅觉上皮层覆盖.
- 在原子化后评估胰岛素免疫活性,以确定药物的完整性.
主要成果:
- 与鼻喷雾相比,NWSAW装置产生了更窄的原子化角度和更小的颗粒.
- 在LBNA配置下,在较低的输入功率下实现了原子化.
- 该Ex-LBNA装置使更深的鼻腔插入成为可能,并成功地在整个嗅觉上皮层中实现了原子化.
- 在使用NWSAW装置原子化后,胰岛素免疫活性在很大程度上被保留.
结论:
- 埃克斯-LBNA系统证明了整个嗅觉上皮的有效,有针对性的原子化.
- 这种定向原子化技术显示了通过鼻内通道向大脑有效输送药物的潜力.
- 在原子化过程中,NWSAW装置保持了像胰岛素这样的生物制药的完整性.
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