证据表明,在皮层-皮层配对关联刺激后,第三视觉路径中增强了向后连接
Pirazzini Gabriele1, Cataneo Antonio2, Pelle Silvana1
1Department of Electrical, Electronic and Information Engineering "Guglielmo Marconi", University of Bologna, Cesena, Italy.
NeuroImage
|January 29, 2026
概括
皮层-皮层配对关联刺激 (ccPAS) 选择性地增强第三视觉通路的向后连接性. 这种对V1/V2通路的后部上角 (pSTS) 的调制,为情感识别提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 大脑的连接性 大脑的连接性
背景情况:
- 后上角 (pSTS) 和早期视觉皮层 (V1/V2) 是"第三视觉通路"的关键组成部分,对于处理社会和情绪信息至关重要.
- 以前的研究表明,从PSTS到V1/V2的皮层-皮层配对关联刺激 (ccPAS) 增强了面部情绪识别,暗示加强了关节连接,但缺乏直接证据.
研究的目的:
- 直接调查ccPAS是否可以在第三视觉通路内调节pSTS和V1/V2之间的定向连接.
- 检查ccPAS协议后连接变化的时间动态和方向性.
主要方法:
- 应用ccPAS与TMS脉冲连续从pSTS传递到V1/V2 (ccPASSTS-V1) 和反向顺序 (ccPASV1-STS) 作为一个控制.
- 在刺激前,刺激后,以及刺激后30分钟的静止状态EEG记录.
- 利用多变量谱格兰杰因果分析来评估方向和频率依赖的功能连接性.
主要成果:
- ccPASSTS-V1在刺激后立即显著增强了pSTS到V1/V2的向后功能连接,效果持续30分钟,与赫比亚类可塑性一致.
- 在ccPASV1-STS后30分钟,在ccPASSTS-V1后在较小程度上观察到向前连接 (V1/V2到psts) 的增加,这可能表明有补偿机制.
- 证明ccPAS可以在第三视觉通路内暂时和选择性调节定向连接.
结论:
- ccPAS可以有效调节定向大脑连接,特别是加强第三视觉通路的向后连接.
- 这些发现为ccPASSTS-V1后观察到的情绪识别改善提供了生理基础,将其与pSTS-to-V1/V2通路中的塑性变化联系起来.
- ccPAS是探测和调节更高阶视觉电路动态的宝贵工具.
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