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在环境度下PFOA和新兴替代品对小鼠和人类微质的影响:一项比较研究

Keyue Wu¹, Shun Zhou¹, Aoxue Tang¹

¹School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 561113, China; Department of Occupational and Environmental Health, School of Public Health, Guizhou Medical University, Guiyang, Guizhou 561113, China.

Environmental research

|January 29, 2026

概括

perfluorooctanoic 酸 (PFOA) 和它的替代品,GenX 和 perfluorobutanesulfonic 酸 (PFBS),导致微质功能障碍. 在人类和小鼠微质中,PFOA的神经毒性比GenX和PFBS更大.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
毒理学毒理学毒理学

背景情况:

perfluorooctanoic 酸 (PFOA) 是一种持久性环境污染物,与神经毒性有关.
像GenX和 perfluorobutanesulfonic acid (PFBS) 这样的短链和多基物质 (PFAS) 正在取代PFOA.
这些PFAS替代品对微质细胞的神经毒性影响仍未得到充分研究.

研究的目的:

为了比较PFOA,GenX和PFBS在人类和小鼠微质上的神经毒性潜力.
研究这些PFAS对微质氧化应激,炎症,细胞和TREM2/SYK信号传递的影响.

主要方法:

人类 (HMC3) 和小鼠 (BV2) 微质被暴露在PFOA,GenX和PFBS的分级度中.
使用PROASTweb软件进行了基准剂量 (BMD) 响应分析.
测量了氧化应激,炎症,细胞活动和信号通路的关键指标.

主要成果:

与GenX和PFBS相比,PFOA的神经毒性潜力更高.
这三种PFAS都诱导了氧化应激,微质激活,受损的细胞化和TREM2/SYK通路失调.
所有测试的PFAS都上调了亲炎性细胞因子表达 (IL-1β,IL-6,TNF-α),PFOA显示出最显著的影响.

结论:

PFOA,GenX和PFBS都会诱导微质功能障碍,其特点是氧化应激,炎症和受损的细胞形成.
神经毒性影响的严重程度按照等级:PFOA>GenX>PFBS.
这项研究提供了传统和新兴PFAS在微质上的神经毒性特征的比较,这对于环境健康风险评估至关重要.

关键词:

微质细胞中的微质细胞神经炎症是一种神经炎症.神经毒性神经毒性氧化应激是一种氧化应激.和多醇基物质是多和多的.

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