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Updated: Jan 31, 2026

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奥巴库诺因激活CRHBP介导的自而减轻西斯胺诱导的耳毒性

Shaoqin Cen1, Zhenxing Hou1, Yuan Zhang2

  • 1Department of Otolaryngology Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Biochemical pharmacology
|January 29, 2026
PubMed
概括

一种天然化合物奥巴库农 (obacunone) 通过激活自而保护免受西斯普拉丁诱导的听力损失. 它调节皮质激素释放激素结合蛋白 (CRHBP),减少毛细胞亡,并提供一种新的自身保护策略.

关键词:
自自是一种自的过程.这就是CRHBP.西斯普拉丁 (Cisplatin) 是一种听力损失 听力损失有一个是obacunone.耳部毒性 耳部毒性

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