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乙醇沉的糖化物:对于Danggui Sini来说,对于抗氧化诱导的神经毒性至关重要

Xiang-Ling Qin¹, Hu-Dong Lv¹, Qi Yang¹

¹Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; Department of Metabolomics, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, 210028, PR China.

Journal of ethnopharmacology

|January 29, 2026

概括

丹古伊西尼的乙醇沉分量 (PAP) 对于治疗氧沙胺诱导的外围神经病变 (OIPN) 是至关重要的. PAP增强了肠道健康和SCFA的产生,补充了用于协同神经保护的上游分数 (SAP).

科学领域:

药理学药理学是指药理学的学科.
神经科学是一个神经科学.
传统中国医药传统中国医药

背景情况:

氧化诱导的周围神经病变 (OIPN) 是化疗的重要副作用.
传统中国医学 (TCM) 将OIPN视为OIPN.

研究的目的:

确定OIPN中Danggui Sini开 (DSD) 的乙醇沉分数 (PAP) 的神经保护作用.
阐明DSD在OIPN治疗中的有效性的潜在机制.

主要方法:

通过乙醇沉将DSD分解成沉物 (PAP) 和超物 (SAP).
在OIPN小鼠模型中评估神经保护,使用行为,组织学和分子分析.
对肠道微生物群,短链脂肪酸 (SCFA),谷氨 (GSH) 循环和Cdk5/p35通路的分析.

主要成果:

无论是PAP还是SAP都改善了OIPN,DSD显示了最好的整体疗效.
PAP显著改善了肠道屏障的完整性和Prevotellaceae_UCG-001的丰富性,同时增加了SCFA的产量 (特别是丁酸盐).
SAP在防止GSH耗尽方面发挥了主要作用,这两种分离物与DSD有协同作用.

结论:

富含糖分的PAP分量对于DSD在治疗OIPN的有效性至关重要.
PAP和SAP通过涉及肠道微生物群,SCFA,GSH循环和Cdk5/p35通路调节的独特机制产生互补的神经保护作用.
这些发现凸显了加工方法在保护DSD等草药的治疗潜力的重要性.

关键词:

Cdk5/p35路径的路径丹古伊·西尼 (Danggui Sini) 蒸煮剂提供葡萄糖的循环周期奥克沙利普拉丁诱导的外围神经病变糖类是一种糖类.短链脂肪酸短链脂肪酸

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