针对脑转移的HER2-阴性乳腺癌的系统治疗的最新进展
Chunfang Hao1, Jie Zhang2, Yuehong Zhu1
1Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China; Department of Breast Oncology, Tianjin Cancer Hospital Airport Hospital, Tianjin 300060, China; Department of Breast Oncology, National Clinical Research Center for Cancer, Tianjin 300060, China.
Critical reviews in oncology/hematology
|January 29, 2026
概括
新的疗法为HER2阴性乳腺癌脑转移 (BCBM) 和乳腺膜病 (LMD) 提供了希望. 抗体-药物合物,CDK4/6抑制剂和内治疗的进展改善了患者的治疗结果和生活质量.
科学领域:
- 在瘤学瘤学.
- 神经瘤学神经瘤学
- 翻译医学是一种翻译医学.
背景情况:
- HER2 阴性乳腺癌脑转移 (BCBM) 和乳腺膜病 (LMD) 具有显著的临床挑战,治疗选择有限.
- 与HER2阳性BCBM不同,HER2阴性BCBM和LMD缺乏标准化的管理协议.
研究的目的:
- 审查 HER2 阴性 BCBM 和 LMD 的全身和直肠内疗法的最新进展.
- 突出在这些具有挑战性的条件下改善生存和生活质量的新兴策略.
主要方法:
- 审查最近的临床数据和新兴的治疗策略.
- 对针对细胞循环调节,DNA修复,免疫调节和特定分子通路的新型药物的分析.
- 对抗体-药物合物 (ADC) 和内疗法对中枢神经系统透和疗效的评估.
主要成果:
- 循环素依赖性激酶4/6 (CDK4/6) 抑制剂在激素受体阳性子组中表现有前途,特别是在放射治疗中.
- 像trastuzumab deruxtecan和sacituzumab govite这样的ADC可以在BCBM中显示出增强的中枢神经系统透和有效性.
- 内疗法对LMD管理至关重要,而新兴药物则针对抗药机制.
结论:
- 在HER2阴性BCBM和LMD管理的景观正在迅速发展,新的治疗选择.
- 迫切需要战略来延长存活时间,并保持生活质量,并具有有利的安全性.
- 个性化治疗方法利用新的全身和内疗法对于更好的患者结果至关重要.
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