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Updated: Jan 31, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
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在CAF丰富的实体瘤模型中,MMP3过度表达增强了CAR-T细胞透和抗瘤活性

Yuge Zhu1, Jiaxin Tu2, Shance Li2

  • 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Surgery II, Peking University Cancer Hospital & Institute, Beijing, People's Republic of China.

Journal for immunotherapy of cancer
|January 29, 2026
PubMed
概括

工程化学抗原受体 (CAR) T细胞共同表达矩阵金属蛋白酶-3 (MMP3) 通过降解细胞外矩阵 (ECM) 有效地透到固体瘤中. 这种MMP3增强可以提高CAR T细胞治疗对具有挑战性的瘤微环境的疗效.

关键词:
收养细胞疗法 - ACT抗原受体设计的设计肺癌 肺癌 是 一种 肺癌.

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