3D打印的pectin-chitosan聚电解质水凝用于控制胃肠道释放和肠直肠向输送
Shinha Hwang1, Kyungjik Yang1, Hyung Sun Yoon2
1Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Carbohydrate polymers
|January 29, 2026
概括
我们开发了3D打印的多糖水凝,用于口服药物输送. 这些增强的水凝提供了更好的机械强度和有针对性的胃肠道释放,为个性化医疗铺平了道路.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 由于生物相容性和刺激反应性,多糖水凝 (pectin和chitosan) 适合于口服.
- 现有的离子交联水凝在消化道中缺乏机械稳定性.
研究的目的:
- 开发具有可调节的机械强度和胃肠道稳定性的3D打印水凝.
- 创建基于多糖的3D打印系统,用于个性化的口服药物输送.
主要方法:
- 使用了多电解质复合和两种交叉连接剂的离子凝.
- 采用基于双滴滴的3D打印,使用纤维素纳米晶体作为支持生物材料墨水.
- 优化了pectin-chitosan和纤维素纳米水晶墨水的质特性和打印能力.
主要成果:
- 与pectin水凝相比,pectin-chitosan水凝显示出2.4倍的增强机械强度和2.0倍的持续释放.
- 水凝显示了结肠向的输送和持续释放,由结肠中的pectinase触发.
- 在3D打印过程中,通过药物定位和表面积的变化实现了精确控制的胃肠道释放.
结论:
- 开发的3D打印系统可以制造具有可调节性质的自由形状和层次结构.
- 这项技术提供了一个平台,用于个性化口服输送生物制药,控制胃肠道释放.
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