具有协同作用的氧化应激和自抑制的ROS响应的基素衍生纳米纤维,用于强大的瘤治疗
Mingxiao Shao1, Yan Peng1, Liyan Qiu1
1Ministry of Education (MOE) Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310058, China.
Carbohydrate polymers
|January 29, 2026
概括
这项研究介绍了一种新的纳米纤维系统,可以放大氧化压力并阻止自,以克服癌症治疗抵抗力. 该系统通过提高活性氧物种 (ROS) 水平,有效地抑制瘤生长.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 瘤的氧化应激治疗受到自的阻碍,自是一种促进抵抗力的生存机制.
- 活性氧物种 (ROS) 是基于氧化应激的癌症治疗中的关键媒介.
研究的目的:
- 设计一种可响应ROS的纳米纤维系统 (CQ/Cu@CT),增强氧化应激并抑制自,以改善癌症治疗.
- 调查设计的纳米微粒的自我放大ROS生成和治疗疗效.
主要方法:
- 合成一种两性橄基托衍生物与ROS响应的硫乙乙 (TA) 前药.
- 自组装成纳米纤维包装 (CQ) 和Cu2+.
- 在体外和体内对ROS生成,自抑制和抗瘤作用的评估.
主要成果:
- 在细胞内ROS检测时,纳米纤维分离,释放甲 (CA),Cu2+和CQ.
- CA和Cu2+协同增强ROS的产生,而CQ抑制保护性自.
- CQ/Cu@CT表明显著的瘤生长抑制 (67.8%) 和诱导免疫细胞死亡 (ICD).
结论:
- 开发的CQ/Cu@CT纳米纤维系统有效增强氧化应激,并克服癌症治疗中的自介导抗性.
- 这一策略有望通过放大ROS并触发免疫反应来开发强效的抗癌治疗方法.
相关概念视频
Responses to Salt Stress
14.6K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.6K
Responses to Heat and Cold Stress
14.8K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.8K
Stress Response System
879
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
Alarm stage
In the alarm stage, the body's...
879
Psychological Responses to Stress
692
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
692
Other Stress Responses in Bacteria
395
Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
395
Autophagy
5.8K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.8K


