一个可穿戴的微针集成多重复光子吸收传感器,用于检测间歇性液体中的非法药物
Manal Bashir1, Saddam Hussain1, Dana Cialla-May2,3
1Department of Chemistry, College of Science, Alfaisal University, Riyadh 11533, Kingdom of Saudi Arabia.
Analytical chemistry
|January 29, 2026
概括
一个新的可穿戴生物传感器阵列使用微针在间歇性液体 (ISF) 中进行最小侵入性药物检测. 这种aptamer功能化的液晶装置提供了敏感,选择性和便携式的海洛因,可卡因和甲基胺查.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 目前的药物检测方法通常需要侵入性程序或复杂的实验室分析.
- 需要便携式,灵敏和最少侵入性的诊断工具来实时监测药物.
研究的目的:
- 开发一个微针集成的可穿戴生物传感器阵列,用于对海洛因,可卡因和甲基胺进行最小入侵检测.
- 为了利用aptamer功能化胆固醇液晶基互穿透聚合物网络 (CLCN-IPNs) 进行色度测试药物检测.
主要方法:
- 使用CLCN-IPN与aptamer功能化的可穿戴生物传感器阵列的制造.
- 传感器阵列与微针集成用于间歇性流体 (ISF) 取样.
- 利用光子带隙 (λPBG) 在CLCN-IPN中转移,用于可见色度测量药物检测.
主要成果:
- 生物传感器阵列对海洛因,可卡因和甲基胺具有很高的选择性和敏感性,检测极限低于1.3 ng/mL.
- 在实验室验证显示,使用肉组织模型,药物恢复准确 (92.5-115%).
- 该设备提供了强大的视觉输出和多重检测能力,通过不同的初始颜色和光谱变化.
结论:
- 开发的微针集成的可穿戴生物传感器阵列为最小侵入性药物检测提供了一个有希望的平台.
- 这种无电池,便携和低成本的设备代表了临床,法医和个人健康领域可穿戴诊断的重大进步.
- 通过CLCN-IPN技术,可以对ISF中的非法物质进行敏感和选择性的色度检测.
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