在奖励响应目标导向行为中,前额前部运动合的因果证据是奖励响应目标导向行为
Justin Riddle1,2,3,4, Lewis P Edwards3,4, Moria Smoski5
1Department of Psychology, Florida State University jriddle@fsu.edu Flavio_frohlich@med.unc.edu.
概括
大型抑郁症 (MDD) 无喜症与受损的奖励响应目标导向行为有关. 针对左前额叶皮层的三角贝塔合与非侵入性脑刺激,在MDD患者中因果地改善了这种行为.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算神经科学是一种神经科学.
背景情况:
- 无情感,主要抑郁症 (MDD) 的核心症状,与麻木的奖励处理有关.
- 连接前额叶皮层功能障碍与无情感的精确电生理机制仍然不太清楚.
- 非侵入性大脑刺激通常针对安赫多尼亚的左侧前额叶皮质,但最佳目标需要机械洞察力.
研究的目的:
- 调查MDD中奖励处理缺陷背后的神经机制,特别关注anhedonia.
- 确定奖励处理的特定组成部分 (努力动机,奖励估值,目标导向行为) 与无症严重程度相关.
- 确定调节前额前部运动神经合是否可以因果地改善MDD中奖励响应目标导向行为.
主要方法:
- 患有MDD的参与者完成了一项适应性-EfRT任务,同时记录了脑电图 (EEG).
- 用光谱和交叉频率合分析来检查奖励处理期间的前额叶和运动皮层活动.
- 交叉频率的横交替电流刺激 (tACS) 应用于调节前额前-动力三角贝塔合,与安慰剂和活性对照相比,行为结果较好.
主要成果:
- 在MDD中,无症的严重程度与的奖励响应目标导向行为最强烈相关.
- 脑电图显示左前额三角形增加和运动皮质β振荡减少,在奖励任务期间这些区域有显著的三角形-β相幅度合.
- 与假冒和主动控制刺激相比,tACS针对前额头运动的三角贝塔合显著改善了奖励响应的目标导向行为.
结论:
- 奖励响应目标导向行为的缺陷是MDD中无情感的关键神经相关物.
- 左前额皮质和运动皮质的三角贝塔交叉频率合是将目标转化为行动的关键机制.
- 针对这种特定的前额前部运动合与非侵入性大脑刺激提供了一个有前途的途径,用于新的MDD干预无症.
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