在抗卵巢癌中比较nab-paclitaxel和基于溶剂的paclitaxel:证据和前景
Jalid Sehouli1, Meghan R Forrest2, Jolijn D Boer3
1Charité-Universitätsmedizin Berlin, European Competence Centre for Ovarian Cancer, Department of Gynecology with Center for Oncological Surgery, Berlin, Germany; North-Eastern German Society for Gynecological Oncology (NOGGO), Berlin, Germany.
概括
纳布-帕克利塔塞尔是用于抗卵巢癌的基于溶剂的帕克利塔塞尔 (sb-paclitaxel) 的可行的替代品,具有可比的疗效和更好的安全性. 专家建议纳布-帕克利塔克塞尔可以提高生活质量,副作用较少.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 帕克利塔克塞尔是用于治疗抗性卵巢癌的标准治疗方法.
- 无溶剂配方Nab-paclitaxel在其他癌症中具有有利的毒性概况,但在这种情况下缺乏与基于溶剂的帕克利塔塞尔 (sb-paclitaxel) 相比的评估.
研究的目的:
- 为了比较nab-paclitaxel与sb-paclitaxel单一治疗在抗卵巢癌中的疗效和安全性.
- 为临床决策和治疗指南提供信息.
主要方法:
- 一种混合方法的方法,结合了系统的文献审查和专家讨论.
- 对 sb-paclitaxel 的随机对照试验 (RCT) 和对 nab-paclitaxel 的随机对照试验/观察性研究的文献搜索.
- 两个跨学科,以患者为中心的研讨会将试验数据与专家判断相结合.
主要成果:
- 没有确定对比的RCT比较nab-paclitaxel和sb-paclitaxel在抗性卵巢癌中.
- 间接证据表明,nab-paclitaxel和sb-paclitaxel之间的疗效相似.
- 纳布-帕克利塔塞尔显示出良好的安全性,避免了Cremophor® EL相关的毒性,并可能允许更高的剂量和更好的生活质量.
结论:
- 纳布-帕克利塔塞尔被认为是对白金耐药卵巢癌的sb-paclitaxel的可行替代品.
- 证据支持与nab-paclitaxel具有相似的疗效和更好的安全性,包括更少的过敏反应.
- 专家认为额外的随机试验是不必要的.
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