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口腔状细胞癌中部分EMT:分子电路和临床翻译
Chunhua Wang1, Motoharu Sarubo1, Siqi Chen1
1Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, 770-8504, Japan.
International journal of oral science
|January 29, 2026
概括
部分上皮层-介质细胞过渡 (EMT) 驱动口腔癌的传播和治疗耐药性. 针对这种侵略性的状态为改善患者的生存率和生活质量提供了新的希望.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 分子瘤学分子瘤学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种常见的癌症,死亡率高,通常与侵袭性瘤生长和转移有关.
- 表皮-介质细胞过渡 (EMT) 是一种细胞过程,增强瘤细胞迁移和入侵.
- 许多OSCC细胞表现出部分EMT状态,其特征是混合的上皮和介质细胞特征,导致侵入性和可塑性增加.
研究的目的:
- 审查部分EMT在OSCC中的作用.
- 探索部分EMT如何影响瘤微环境 (TME),癌症干细胞 (CSCs),入侵和转移.
- 讨论针对部分EMT的治疗策略,以改善OSCC结果.
主要方法:
- 对多主题研究和癌症EMT研究的文献综述.
- 分析部分EMT对OSCC进展和治疗耐药性的影响.
- 综合当前关于治疗策略中针对部分EMT的知识.
主要成果:
- 部分EMT是OSCC入侵,转移和CSC特征的关键驱动因素.
- 这种混合状态显著改变了瘤微环境.
- 部分EMT与对癌症治疗的耐药性密切相关.
- 针对部分EMT是一个有前途的治疗途径.
结论:
- 部分EMT在OSCC进展,TME调制和治疗耐药性方面发挥着关键作用.
- 旨在针对部分EMT的治疗策略有可能提高治疗疗效.
- 专注于部分EMT的干预可以显著提高OSCC患者的生存率和生活质量.
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