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Updated: Jan 31, 2026

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
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Published on: July 29, 2022

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抗TLR2免疫疗法在小鼠和人类模型中调节α-synuclein在神经元到寡聚细胞的传播

Eun-Jin Bae1, Sangwoo Ham2,3, Yeonwoo William Jeong4

  • 1Neuroscience Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea.

Nature communications
|January 29, 2026
PubMed
概括

通过Toll-like受体2 (TLR2) 将α-synuclein (αSyn) 从神经元扩散到质质细胞,导致多个系统缩 (MSA) 中的质细胞质内含. 抗TLR2疗法减少了病理和脱髓化,这表明MSA的潜在疾病修饰治疗.

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