静态和动态功能连接密度的共同点和区别 左侧和右侧叶
Chengru Song1,2, Xiaonan Zhang3, Jingliang Cheng3
1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. songchengru@126.com.
Scientific reports
|January 29, 2026
概括
左和右叶 (LTLE和RTLE) 显示叶连接性减少. LTLE表现出广泛的脑部变化,而RTLE影响叶和小脑,揭示出不同的网络模式.
科学领域:
- 神经科学是一个神经科学.
- 的研究研究.
- 大脑的连接性 大脑的连接性
背景情况:
- 叶 (TLE) 是一种复杂的神经系统疾病.
- 了解左 (LTLE) 和右 (RTLE) TLE 的网络变化对于诊断和治疗至关重要.
- 静态和动态功能连接密度 (FCD) 为大脑网络功能提供了洞察力.
研究的目的:
- 为了比较LTLE和RTLE患者的静态和动态FCD与健康对照 (HCs).
- 调查LTLE和RTLE之间不同的网络中断配置文件.
- 探索认知功能与FCD/dFCD之间的关系.
主要方法:
- 从46名LTLE,43名RTLE和53名HC参与者获得T1加权的结构和静止状态功能图像.
- 使用滑窗方法测量和比较静态FCD和动态FCD (dFCD).
- 基于种子的功能连接 (FC) 分析和与认知得分的相关性.
主要成果:
- 与HC相比,LTLE和RTLE都显示出较低的ipsilateral叶静态FCD.
- LTLE在逆侧叶表现出FCD的减少,而RTLE在左叶表现出FCD/dFCD的增加,并在左小脑表现出dFCD的减少.
- FC分析揭示了LTLE中更多异常区域,在RTLE中出现了特定的左叶FC减少.
结论:
- TLE是一种系统级疾病,具有横向网络表型.
- 与RTLE相比,LTLE具有更多的双边和广泛的网络修改.
- 整合静态和动态FCD可以全面了解TLE的全脑网络异常.
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