环境风险因素和多发性硬化症转换在放射隔离综合征的受试者:一个病例控制研究研究
Chiara Zanetta1,2, Antonino Giordano3,4, Francesco Laserra1
1Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Journal of neurology
|January 29, 2026
概括
某些青少年因素,如体重不足,怀孕损失和辅助生殖技术的使用,增加了放射性隔离综合征 (RIS) 进展为多发性硬化症 (MS) 的风险. 儿童户外活动与临床隔离综合征/复发性复发性MS发病风险较低有关.
科学领域:
- 神经学 神经学
- 环境医学 环境医学
- 流行病学 流行病学
背景情况:
- 放射性隔离综合征 (RIS) 的特征是MRI检测到的病变,这些病变是无症状个体的多发性硬化症 (MS) 的典型特征.
- 了解与RIS发展为临床事件相关的环境因素对于早期干预至关重要.
研究的目的:
- 研究与放射隔离综合征 (RIS) 患者首次临床事件相关的环境因素.
- 确定从RIS转化为临床明显的多发性硬化症 (MS) 的风险因素.
主要方法:
- 一项病例对照研究,将RIS患者与在发病时呈现临床隔离综合征 (CIS) 或复发性复发性多发性硬化症 (RRMS) 的个人进行比较.
- 环境调查问卷用于评估生活方式因素.
- 进行了统计分析,以确定RIS患者转换的风险因素.
主要成果:
- 在童年期间在户外度过更多时间与CIS/RRMS发病风险降低有关.
- 在5年内转化为MS的RIS患者在青春期更有可能体重不足 (HR 11.57).
- 在RIS诊断之前,怀孕损失 (HR 4.48) 和使用辅助生殖技术 (ART) (HR 20.42) 与转化风险增加有关.
结论:
- 青少年体重不足状况,怀孕损失和ART使用是从RIS转化为MS的重要风险因素.
- 较高的儿童户外活动可能有助于防止CIS/RRMS的发展.
相关概念视频
Factors Affecting the Risk of Infection
13.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
Gene Conversion
10.6K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.6K
Gene Conversion
3.0K
3.0K
Bioavailability Study Design: Healthy Subjects Versus Patients
154
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
154
Combinatorial Gene Control
9.7K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.7K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
467
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
467


