循环瘤DNA动态预测了病理反应,并在新辅助环境中指导治疗个性化
Hani Moslem Ahmed1, Ali Fawzi Al-Hussainy2, Wael Waleed Mustafa3
1College of Pharmacy, Alnoor University, Nineveh, Iraq.
Discover oncology
|January 29, 2026
概括
循环瘤DNA (ctDNA) 在新辅助疗法期间提供实时监测,预测治疗反应和生存率. 这种动态生物标志物方法使个性化治疗调整成为可能,改善了癌症患者的治疗结果并降低了癌症患者的毒性.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
- 生物标志物研究 生物标志物研究
背景情况:
- 新辅助疗法评估传统上是延迟的,导致"黑子"时期,可能导致无效或有毒的治疗方法.
- 循环瘤DNA (ctDNA) 正在成为实时监测瘤负担的动态生物标志物.
研究的目的:
- 审查ctDNA作为新辅助治疗中的动态生物标志物的潜力.
- 探索ctDNA动态如何预测各种固体瘤的治疗反应和存活率.
主要方法:
- 对新辅助环境中ctDNA动态现有文献的审查.
- 分析ctDNA清除动力学及其与病理反应和生存结果的相关性.
主要成果:
- 通过液体活检进行序列ctDNA监测,可提供瘤负担的非侵入性实时评估.
- 快速的ctDNA清除预测了有利的结果,并支持治疗降级.
- 持久的ctDNA识别了非响应者,表明治疗加剧的潜在益处.
结论:
- ctDNA动态是新辅助治疗疗效和患者存活率的强有力的预测指标.
- 测试标准化和低分泌瘤等挑战需要解决,以便在临床采用.
- 使用人工智能将ctDNA与其他数据集成,可以个性化新辅助护理,优化疗效并最大限度地降低毒性.
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