Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

259
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
259
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

304
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
304
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

223
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
223
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

564
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
564
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

2.5K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
2.5K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Tumor-Infiltrating Lymphocytes as Predictors of Response to Neoadjuvant Chemotherapy in Breast Cancer: Added Value of Morphological Characterization Beyond Quantification.

Cancers·2026
Same author

DNA methylation signatures distinguish extranodal NK/T-cell lymphoma and EBV-positive nodal T/NK-cell lymphoma and identify prognostic subgroups.

Leukemia·2026
Same author

Pharmacological activation of NO-cGMP signalling attenuates metabolic dysfunction-associated steatohepatitis.

British journal of pharmacology·2026
Same author

Nodular lymphocyte-predominant Hodgkin lymphoma controversy and insights: a global NLPHL one working group summit report.

Leukemia·2026
Same author

Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma.

Leukemia·2026
Same author

Noninvasive in vivo imaging of NF-κB activation predicts immunotherapy response in solid tumors.

Npj imaging·2026

相关实验视频

Updated: Jan 31, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.5K

[儿童淋巴瘤的诊断挑战]

Jan Bosch-Schips1,2, Leticia Quintanilla-Martinez1,3, Falko Fend4

  • 1Institut für Pathologie und Neuropathologie und Referenzzentrum für Hämatopathologie, Universitätsklinikum Tübingen, Liebermeisterstraße 8, 72076, Tübingen, Deutschland.

Pathologie (Heidelberg, Germany)
|January 29, 2026
PubMed
概括

儿科淋巴瘤很少见,与成人类型不同. 本综述涵盖了它们的分类,生物学和诊断,强调了罕见的惰形式和淋巴瘤模仿,以准确识别.

关键词:
IRF4重新排列的大B细胞淋巴瘤.无意识的B细胞淋巴瘤淋巴瘤模仿反应性扩散.儿科毛囊性淋巴瘤 儿科毛囊性淋巴瘤儿科淋巴瘤 儿科淋巴瘤

更多相关视频

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
03:37

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry

Published on: June 6, 2025

463
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

1.8K

相关实验视频

Last Updated: Jan 31, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.5K
Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
03:37

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry

Published on: June 6, 2025

463
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
07:59

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

1.8K

科学领域:

  • 儿科血液学 瘤学 儿科血液学
  • 瘤生物学 瘤生物学
  • 诊断病理学的诊断病理学

背景情况:

  • 儿科淋巴瘤构成所有淋巴瘤的一小部分,与成人病例相比,具有独特的亚型分布,分子特征和预后.
  • 由于儿科淋巴瘤的异质性以及模仿恶性瘤的反应性淋巴细胞扩散的存在,准确的分类和诊断至关重要.

研究的目的:

  • 审查目前儿童淋巴瘤的分类,生物学和诊断方面的进展.
  • 专注于罕见的惰性亚型和模仿儿童和青少年淋巴瘤的反应性病变.

主要方法:

  • 关于儿科淋巴瘤的综合文献综述.
  • 对分类系统的最新更新进行分析,包括世卫组织儿童瘤分类.
  • 讨论诊断挑战,差异诊断和特定实体.

主要成果:

  • 常见的儿科淋巴瘤包括伯基特淋巴瘤,淋巴细胞淋巴瘤,霍奇金淋巴瘤和ALK阳性形大细胞淋巴瘤.
  • 罕见的惰性亚型,如儿科类型的卵泡淋巴瘤和儿科结节边缘区域淋巴瘤,预后很好.
  • 积极的亚型,如IRF4重新排列的大B细胞淋巴瘤和11q异常的高等级/大B细胞淋巴瘤,也显示出有利的结果.
  • 反应性淋巴细胞增殖 (例如,传染性单核病,基库奇-藤本病) 存在诊断方面的挑战.

结论:

  • 儿科淋巴瘤是一个异质的群体,具有明显的临床和生物特征.
  • 准确的诊断需要仔细区分罕见的惰实体,新定义的大B细胞淋巴瘤和反应性模仿.
  • 最近的分类越来越多地纳入了儿童淋巴瘤的这些独特方面.