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Zhitao Cai¹, Hanyan Gong¹, Sishu Li¹

¹School of Pharmacy, Shenyang Pharmaceutical University, Shenhe District, No. 103 Wenhua Road, Wulihe Subdistrict, 110016, Shenyang, Liaoning, People's Republic of China.

AAPS PharmSciTech

|January 29, 2026

概括

一种新的纳米悬浮微囊系统显著改善了天然脂友性颜料 (如黄素和黄蛋白) 的溶解,稳定性和加工,用于制药用途.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

自然的脂性颜料 (如黄素,黄蛋白) 具有较差的水溶性,低溶解率和光热不稳定性,限制了它们的制药应用.
开发有效的输送系统对于提高这些有价值化合物的生物可用性和稳定性至关重要.

研究的目的:

开发和优化一个纳米悬浮-微囊输送系统,用于天然的脂友性颜料.
为了提高黄素和黄蛋白的溶解,稳定性和粉末特性,用于制药配方.

主要方法:

库尔库明 (CUR) 和黄蛋白 (LUT) 的纳米悬浮 (NS) 用抗溶剂沉制备,并通过湿媒体研磨进行优化,使用基甲基纤维素E5 (HPMC-E5) 作为稳定剂.
纳米悬浮被通过喷雾干燥和以糖为基础的核心涂层流化床转化为微囊.
评估了表面修饰和粉末特性 (流动性,可压缩性).

主要成果:

与原料颜料相比,黄素-NS和黄素-NS的溶解速度显著提高 (CUR-NS: 5 分钟内93.3%; LUT-NS: 120 分钟内85.1%).
通过流化床涂层进行微封装,产生了具有出色流动性 (静止角~20°) 和直接压缩适度的微囊.
加速稳定性测试表明,与原料颜料相比,微囊对热,光和湿度的耐受性提高了1.3至4倍.

结论:

开发的纳米悬浮微封装策略有效地提高了难溶性天然颜料的溶解,稳定性和加工性能.
这种方法对天然颜料在制药中的工业配方和应用具有重大前景.

关键词:

库尔库明是一种黄素.黄蛋白质 (lutein) 是一种蛋白质.微装封装是一种微装封装.这是一种纳米悬浮.天然颜料是一种天然的颜料.

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