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Updated: Jan 31, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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双重COX-2/CaV2.2抑制剂的设计和表征具有强烈的止痛活性

Jie Qiu1, Shouwei Tao1, Tian Zhang1

  • 1Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Journal of medicinal chemistry
|January 29, 2026
PubMed
概括

一种针对循环氧化酶-2 (COX-2) 和N型通道 (CaV2.2) 的新型双重抑制剂显示出强大的疼痛缓解作用. 化合物5d有效降低炎症和神经信号,为慢性疼痛管理提供了一个有前途的多机制方法.

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