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超热性腹腔内化疗对晚期结直肠癌患者的影响:系统性审查和元分析

Ziying Su^1,2, Yong Guo², Xiaosong Ru³

¹The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.

World journal of surgical oncology

|January 30, 2026

概括

超热性腹膜内化学疗法 (HIPEC) 在改善晚期结直肠癌 (CRC) 的生存率和减少腹膜转移方面表现有前途. 然而,血栓和中性的风险增加需要仔细考虑其使用.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
胃肠病学胃肠病学

背景情况:

晚期结肠直肠癌 (CRC) 经常导致腹转移 (PM),显著降低患者的存活率.
超热腹腔内化疗 (HIPEC) 在治疗PM或PM风险的晚期CRC中的作用仍在调查中.

研究的目的:

评估HIPEC在改善生存结果和减少晚期结直肠癌患者腹复发中的有效性.
评估HIPEC对腹转移率和相关并发症的影响.

主要方法:

在2024年4月之前发表的队列研究和随机对照试验 (RCT) 的系统文献综述和元分析.
搜索了包括PubMed,Cochrane,Embase和Web of Science在内的数据库.
分析了总生存率 (OS),无病生存率 (DFS),总复发率 (ORR),PM率和并发症的数据,使用GRADE评估证据质量.

主要成果:

在先进的CRC中,HIPEC表现出1年的DFS和5年的OS显著改善.
高密度降低了整体PM率,并显示在高风险的CRC中具有预防作用,没有先前的PM.
作为与HIPEC相关的并发症,观察到血栓减退和中性减退的发病率增加.

结论:

在先进的CRC中,HIPEC可以提高生存率并减少腹复发.
诸如血栓减退和中性质减退等并发症需要仔细考虑.
需要进一步进行高质量的RCT,以确定HIPEC在先进CRC管理中的作用.

关键词:

结肠直肠癌是一种癌症.复杂性复杂性复杂性超热内内化学疗法超热内内化学疗法复发情况复发情况幸存的生存方式

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