慢性牙周炎和老年人的全身炎症:对神经退行症的影响
Hyun Jung Kwon1, Ji Hyeon Ahn2, Moo-Ho Won3
1Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, 25457, Korea.
Journal of neuroinflammation
|January 30, 2026
概括
慢性牙周炎与口腔细菌有关,可能导致神经炎症和认知能力下降. 优化口腔健康可能是预防老年人群神经退行性疾病的关键.
科学领域:
- 神经科学是一个神经科学.
- 牙周病学 牙周病学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性牙周炎越来越多地与神经退行性疾病有关.
- 系统性炎症,微生物失生症和血脑屏障 (BBB) 变化是关键机制.
- 口腔病原体和失生菌群可能引发神经炎症级联.
研究的目的:
- 综合关于神经退行症中口腔-大脑轴的证据.
- 探索将牙周病与认知衰退联系在一起的机制.
- 讨论关于口腔-大脑轴的潜在干预措施.
主要方法:
- 对人类和实验研究的审查.
- 对口腔大脑病理学的机制性见解的分析.
- 对生物标志物和成像数据的检查.
- 讨论多学科和精准医学框架.
主要成果:
- 牙周病原体如 Porphyromonas gingivalis 与神经炎症有关.
- 质激活和细胞因子调解口腔-大脑病理.
- 慢性牙周炎症与神经血管功能障碍相关.
- 针对口腔健康的干预措施显示出前景.
结论:
- 口腔-大脑轴是神经退行的一个关键途径.
- 优化口腔卫生和开发有针对性的疗法至关重要.
- 综合性方法可以帮助评估风险和预防更健康的认知衰老.
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