氧化硫酸盐片用于复发性植入失败的患者:双盲,随机,安慰剂对照试验
Dong-Lin Han1,2, Li Li1,3,2,4,5, Jing Shi6
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Third Hospital, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing, 100191, China.
Trials
|January 30, 2026
概括
这项随机对照试验旨在调查氧化是否能改善复发性植入失败 (RIF) 的妇女的活产率. 这项研究将在接受试管婴儿/ICSI的患者中将酸硫酸与安慰剂进行比较.
科学领域:
- 生殖医学 生殖医学
- 临床试验 临床试验
- 免疫调节是一种免疫调节.
背景情况:
- 复发性植入失败 (RIF) 是辅助生殖技术的一个重大挑战.
- 尽管临床证据有限,但Hydroxychloroquine (HCQ) 越来越多地用于RIF的非标签.
- 一个强大的随机对照试验 (RCT) 对于验证HCQ在RIF中的疗效至关重要.
研究的目的:
- 为了确定氧化是否改善RIF患者的怀孕结果.
- 为了比较HCQ和安慰剂组之间的活产率.
- 分析二次结果,包括妊娠并发症和不良事件.
主要方法:
- 一项随机对照试验,涉及686名参与者在5个中心接受IVF/ICSI.
- 参与者将接受硫酸氧化或安慰剂.
- 治疗持续时间从子宫内膜制备到怀孕12周或移植后14天.
主要成果:
- 主要结果:活生生的出生率.
- 二次结果:生化和临床怀孕率,堕胎率,出生体重和并发症.
- 收集有关先天性异常和不良事件的数据.
结论:
- 这项RCT将提供关于氧化对RIF有效性的关键证据.
- 对妊娠并发症的比较分析将为临床实践提供信息.
- 这项研究旨在解决围绕RIF中HCQ使用的临床不确定性.
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