作为调解者的肺功能:在中老年和老年中国成年人中弥合尾骨肌群和痴呆症
Hong Ding1, Yaning Yu2, Laiguo Han1
1College of Humanities and Health Sciences, Bengbu Medical University, Bengbu, 233030, China.
European journal of medical research
|January 30, 2026
概括
更高的尾骨肌量 (ASM) 和更好的肺功能 (LF) 与更低的痴呆风险有关. 肺功能部分介于肌肉质量和痴呆症之间的关系,这表明保存策略可能会防止认知能力下降.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 尾骨肌量 (ASM) 和痴呆风险之间的关联尚未完全理解.
- 研究肺功能 (LF) 在ASM-痴呆症关系中的调解作用对于理解认知健康至关重要.
- 这项研究探讨了老年人群中肌肉质量,肺功能和痴呆症之间的不清楚联系.
研究的目的:
- 为了检查尾骨肌量 (ASM) 和痴呆症之间的关系.
- 确定肺功能 (LF) 是否调解ASM和痴呆症之间的关联.
- 在横截面和纵向上下文中分析这些关系.
主要方法:
- 利用了来自中国健康与退休长度研究 (CHARLS) (2011-2018) 8,391名参与者的数据.
- 采用多变量逻辑回归和Cox比例危险模型来评估ASM,LF和痴呆风险.
- 使用R包"调解"进行因果调解分析,使用非参数引导方法.
主要成果:
- 较高的ASM与较低的痴呆症患病率 (横截面) 和降低的痴呆症风险 (纵向) 有显著的关联.
- 改善的LF显示出强烈的非线性关联,与较低的痴呆症患病率和降低的痴呆症风险有关.
- 肺功能 (LF) 介导了ASM-痴呆症链接的14.10%的横截面和24.22%的纵向.
结论:
- 更高的ASM和更好的LF都独立地与更低的痴呆风险有关.
- 肺功能部分介导ASM对痴呆的保护作用.
- 保持肌肉质量和肺功能可能是预防老年痴呆症的关键策略.
相关概念视频
Changes in the Appendicular Skeleton with Age
3.5K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.5K
Axial and Appendicular Muscles
2.7K
Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
2.7K
What is the Skeletal System?
57.1K
Overview
57.1K
Classification of Skeletal Muscle Fibers
59.5K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.5K
Overview of Skeletal Muscle
14.6K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
14.6K
Relaxation of Skeletal Muscles
5.8K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
5.8K


