患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的患者的多菌株协生和生活方式改变:一种随机双盲安慰剂控制的随机试验
Masoud Faghieh Dinavari1, Samaneh Abbasian1, Amirreza Jabbaripour Sarmadian1
1Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
European journal of medical research
|January 30, 2026
概括
多菌株协生菌与生活方式改变相结合,改善了MASLD患者的脂质样本,肝功能和炎症. 这种协生疗法对管理代谢相关的脂肪性肝病进展具有前途.
科学领域:
- 胃肠病学和肝病学
- 微生物组研究 微生物组研究
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢相关的脂肪性肝病 (MASLD) 是一个普遍的全球健康问题.
- 目前对MASLD益生菌补充剂的研究受到研究质量和样本大小的限制.
- 需要进行经过精心设计的试验,研究用于MASLD管理的多菌株协生菌.
研究的目的:
- 为了评估一个多菌株协同生物的疗效结合生活方式的修改在患有MASLD的患者.
- 评估协生菌对人体测量,血液学,凝血,脂质,血糖,肝功能和炎症标志物的影响.
- 确定协生菌是否可以作为控制MASLD进展的辅助疗法.
主要方法:
- 一个随机,双盲,安慰剂对照试验,涉及80名MASLD患者.
- 参与者接受了多菌株协生菌 (Bifidobacteria,Lacticaseibacillus,Lactobacillus,Streptococcus和Fructooligosaccharides) 或安慰剂12周,以及改变生活方式.
- 综合性评估包括人体测量,血液学,凝血,脂质概况,FBS,肝功能测试和炎症生物标志物.
主要成果:
- 没有观察到人类测量指标的显著变化.
- 与安慰剂相比,共生组的脂质配置 (TC,LDL-C),禁食血糖 (FBS),肝功能 (ALT,AST) 和炎症标志物 (TNF-α,IL-6) 显著改善.
- 血液学参数,凝血状态和其他脂质标记 (TG,HDL-C) 没有显著变化. 补充剂的耐受性很好.
结论:
- 多菌株共生补充剂,当与生活方式修改相结合时,显示出作为MASLD有效的辅助疗法的潜力.
- 这种方法可能有助于控制与代谢相关的脂肪性肝病患者的疾病进展.
- 进一步的研究可以建立在这些发现的基础上,以优化对MASLD的共生干预措施.
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