新出现的MT27耐宏抗 Bordetella pertussis 的分子分析,神户,日本,2025年
Emerging infectious diseases
|January 30, 2026
概括
2025年,一种新型的抗宏类百日咳 Bordetella pertussis (MRBP) MT-27 在日本出现. 遗传分析表明,这种菌株与在中国发现的菌株有关,而不是日本本地菌株.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 百日咳 Bordetella 导致百日咳. 百日咳.
- 百日咳的宏类耐药性是一个日益严重的公共卫生问题.
- 多位数变量数组重复分析 (MT-27) 是一种常见的打字方法.
研究的目的:
- 调查在日本神户市出现的抗巨抗 Bordetella pertussis (MRBP) 的出现和遗传起源.
- 为了确定新出现的MT-27 MRBP和现有的B. pertussis菌株之间的关系.
主要方法:
- 全基因组测序 Bordetella pertussis 隔离物的.
- 对比的基因组分析.
- 多位数变量数串联重复分析 (MT-27) 类型化.
主要成果:
- 2025年,在日本神户发现了多部位变数并列重复分析类型27 (MT-27) 宏抗性百日咳 (MRBP) 的出现.
- 全基因组测序表明,MT-27 MRBP菌株并非起源于日本普遍存在的对化物敏感的MT-27 B. pertussis.
- 日本的MT-27 MRBP菌株与之前在中国发现的MRBP菌株有着密切的遗传关系.
结论:
- 在日本出现MT-27 MRBP代表着一个独特的引入事件.
- 这些发现表明,抗化物耐药的Bordetella pertussis菌株的潜在国际传播.
- 进一步监测至关重要,以监测B. pertussis中抗生素耐药性的传播和演变.
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