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相关概念视频

RNA Stability01:53

RNA Stability

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Classification of Skeletal Muscle Fibers01:48

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Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
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Muscles of the Eye01:20

Muscles of the Eye

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The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
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Muscles that Move the Head01:19

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The muscles that move the head are a dynamic and complex group of structures that work together to facilitate a wide range of head movements, including rotation, flexion, extension, and lateral bending.
The bilateral sternocleidomastoid, or SCM, and the suprahyoid and infrahyoid muscles are significant head flexors. The SCM muscles originate at the sternum and clavicle and attach to the mastoid process of the temporal bone. The SCM contracts bilaterally to bend the head forward, whereas...
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The abdominal wall encircles the abdominal cavity, providing flexible protection and shielding the internal organs from harm. It is bordered at the top by the xiphoid process and costal margins, at the back by the vertebral column, and at the bottom by the pelvic bones and inguinal ligament. The abdominal wall is divided into two regions — the anterolateral and posterior regions.
Anterolateral Region
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Nine muscles are involved in arm movements. Two of these, the pectoralis major and latissimus dorsi, originate from the axial skeleton and are called axial muscles. The other seven originate from the scapula and are called the scapular muscles.
The pectoralis major has two origins. Its clavicular head originates on the medial half of the clavicle. In contrast, the sternocostal head originates on the costal cartilages of ribs 1-6, the sternum, and the aponeurosis of the external oblique of the...
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相关实验视频

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Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice
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EIF4A3诱导的循环RNAcirSnd1通过稳定EEF1A1促进肌肉缩和肌肉衰老.

Jin Li1,2, Bing Jin1,2, Yuwei Yan1,2

  • 1Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Sciences, Shanghai University, Nantong, China.

Journal of cachexia, sarcopenia and muscle
|January 30, 2026
PubMed
概括

循环RNA circSnd1通过稳定EEF1A1蛋白来促进肌肉缩和衰老. 抑制circSnd1可以改善肌肉消耗,为肌肉缩提供潜在的治疗点.

关键词:
EEF1A1 无处不在的存在欧洲投资基金4A3A3在FAT10和FAT10中.一个圆周.肌肉老化 肌肉老化肌肉缩 肌肉缩 肌肉缩

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相关实验视频

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科学领域:

  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学
  • 老年学是一门学科.

背景情况:

  • 肌肉缩是衰老和慢性疾病的重要并发症.
  • 目前用于肌肉缩的治疗干预措施有限.
  • 循环RNAs (circRNAs) 在肌肉缩中的作用在很大程度上仍未被探索.

研究的目的:

  • 研究circSnd1在肌肉缩和衰老中的功能和机制.
  • 为了识别参与肌肉消耗的circRNAs.

主要方法:

  • 在肌肉缩模型和老化肌肉中进行circRNA测序和定量实时PCR.
  • 功能获取和功能丧失实验,以评估circSnd1的作用.
  • 接下来是质谱法 (RIP-MS) 和RIP测定以阐明分子机制.

主要成果:

  • circSnd1,来自SND1基因的保存 circRNA,在肌肉缩模型和老人和老鼠肌肉中被上调.
  • 在细胞和动物模型中,circSnd1促进肌肉缩和衰老.
  • circSnd1表达受到EIF4A3的调节,并通过FAT10相互作用稳定EEF1A1蛋白,减少EEF1A1无处不在,从而促进肌肉缩.

结论:

  • circSnd1被确定为一种促进肌肉缩和衰老的新型circRNA.
  • circSnd1代表了对抗肌肉消耗疾病的潜在治疗目标.