研究乳腺癌幸存者对心血管结果的时间变化的预测效应
Ingunn Fride Tvete1, Marianne Klemp2
1Department of Statistical Modelling and Machine Learning, Norwegian Computing Center, Oslo, Norway. Ingunn.fride.tvete@nr.no.
Journal of breast cancer
|January 30, 2026
概括
乳腺癌患者的心血管疾病风险随着时间的推移因分子亚型而异. 心力衰竭风险特别受到亚型的影响,突出了个性化监测策略的必要性.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 对乳腺癌 (BC) 幸存者来说是一个重大问题.
- 心血管疾病的预后因素可以随着时间的推移而变化,并且根据心血管疾病的类型而异.
- 了解这些动态对于有效的患者管理至关重要.
研究的目的:
- 检查BC患者中六种心血管疾病首次发生的时间.
- 为了研究分子亚型对心血管疾病风险的影响,根据年龄,瘤阶段和放射治疗进行调整.
- 分析BC分子亚型与心血管疾病发病率之间的时间依赖关系.
主要方法:
- 利用了挪威癌症登记处诊断出BC的36605名妇女的数据.
- 雇佣的考克斯回归分析将死亡作为六种心血管疾病的竞争风险.
- 应用随机生存森林 (RSF) 分析以捕捉非线性和时间变化的关系.
主要成果:
- 分子亚型和时间到第一个CVD之间的关联在不同的CVD类型中有所不同.
- 心力衰竭 (HF) 风险与分子亚型有非线性关系.
- 分子亚型是时间对第一个HF的第二个最重要的预测因素,仅次于年龄.
结论:
- 心力衰竭的时间依赖于乳腺癌分子亚型,以时间依赖的方式.
- 随机生存森林分析有效地识别了复杂的预测因素与生存关系.
- 这些发现强调了在对BC患者的心血管疾病风险评估中考虑分子亚型的重要性.
相关概念视频
Gradually Varying Flow
436
Gradually varying flow (GVF) in open channels describes situations where water depth changes slowly along the channel due to factors like non-uniform bed slope, channel shape variations, or obstructions. This flow type occurs when the depth adjusts gradually to balance gravitational forces, shear forces, and energy requirements, resulting in a low rate of depth change.Characteristics of Gradually Varying FlowGVF is commonly observed in natural streams, rivers, and canals, where flow depth...
436
Rapidly Varying Flow
493
Rapidly varying flow (RVF) in open channels is characterized by abrupt changes in flow depth over a short distance, with the rate of depth change relative to distance often approaching unity. These flows are inherently complex due to their transient and multi-dimensional nature, making exact analysis difficult. However, approximate solutions using simplified models provide valuable insights into their behavior.Key Features of Rapidly Varying FlowRVF is commonly observed in scenarios involving...
493
Predicting Reaction Outcomes
10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Outcomes of Glycolysis
107.1K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.1K
Overview of the Cardiovascular System
11.8K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
11.8K
Framing Effects
7.9K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.9K


