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在患有多发性硬化症的成年人中使用ozanimod的现实体验
Jessica Cooperrider1, Jeffrey Lambe2, Michelle Chu3
1Cleveland Clinic, Neurology, Cleveland, OH, USA.
Neurodegenerative disease management
|January 30, 2026
概括
对于复发性多发性硬化症 (MS) 的ozanimod治疗在现实研究中显示出良好的持久性和耐受性. 这种药物在一年内显著减少了复发和MRI病变.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 奥萨尼莫德是一种S1PR调节器,已被批准用于复发性MS.
- 关于ozanimod使用的现实世界数据有限.
- 这项研究评估了ozanimod在临床实践中的应用.
研究的目的:
- 评估患者处方ozanimod的特征.
- 在一年内评估ozanimod的持久性,耐受性和安全性.
- 确定ozanimod在减少MS活动方面的有效性.
主要方法:
- 在两个中心从成年患有MS或CIS的成年人收集回顾性数据.
- 包括206名被处方ozanimod的患者.
- 对患者人口统计,治疗原因,持续性和临床/放射性结果的分析.
主要成果:
- 71%的患者之前有DMT经验;常见的转换原因是成本和不耐受性.
- 72%的患者在12个月后仍在服用ozanimod;由于副作用而停药发生在10.2%的患者中.
- 观察到每年复发率 (56%),新增/扩大的T2病变 (6.6%与40%相比) 和加多增强病变 (3.9%与27%) 的显著减少.
结论:
- 在现实世界MS队列中,ozanimod表现出良好的耐受性和持久性.
- 这种治疗显示出良好的安全性.
- 奥扎尼莫德有效地降低了MS疾病活动的临床和放射性标志物.
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