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Updated: Jan 31, 2026

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地中海饮食与多发性硬化症发展之间的关联:系统性审查和元分析
Fatemeh Shakouri1, Morteza Lotfi1, Ali Rostami1
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Brain and behavior
|January 30, 2026
概括
坚持地中海饮食 (MedDiet) 可能会降低患多发性硬化症 (MS) 的几率. 然而,目前的证据有限,需要进一步的研究来确认MedDiet在MS的预防作用.
科学领域:
- 神经学 神经学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种慢性炎症性中枢神经系统疾病.
- 关于地中海饮食 (MedDiet) 对MS发展的影响存在相互矛盾的证据.
- 需要进行系统审查,以澄清MedDiet与MS的关联.
研究的目的:
- 系统地审查和分析调查MedDiet坚持和MS发展之间的关联的研究.
- 评估MedDiet在多发性硬化症中的潜在预防作用.
主要方法:
- 在PubMed,Embase,Web of Science和Scopus的系统文献搜索到2024年3月.
- 包括最初的临床研究来评估MedDiet的坚持和MS的发展.
- 使用CMA4软件进行元分析,使用JBI工具进行偏差风险评估.
主要成果:
- 包括8项研究 (5个病例控制,3个队列).
- 病例控制研究表明,MedDiet的坚持降低了MS的几率;队列研究没有发现显著的关系.
- 分析显示,高的MedDiet坚持和MS几率之间存在显著的反向关联 (OR:0.275,p<0.01).
结论:
- 分析表明,更高的MedDiet坚持与减少MS几率有关.
- 总体而言,证据缺乏强有力的支持MedDiet在MS的预防作用.
- 由于研究的局限性和异质性,需要进行进一步的精心设计的前性研究.
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